AustralieFrV1, Main, Exploration, bibRecord, 005B38

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Identifieur interne : 005B38 ( Main/Exploration ); précédent : 005B37; suivant : 005B39

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Auteurs : Fadi J. Charchar [Australie] ; Lisa D. S. Bloomer [Royaume-Uni] ; Timothy A. Barnes [Royaume-Uni] ; Mark J. Cowley [Australie] ; Christopher P. Nelson [Royaume-Uni] ; YANZHONG WANG [Royaume-Uni] ; Matthew Denniff [Royaume-Uni] ; Radoslaw Debiec [Royaume-Uni] ; Paraskevi Christofidou [Royaume-Uni] ; Scott Nankervis [Australie] ; Anna F. Dominiczak [Royaume-Uni] ; Ahmed Bani-Mustafa [Australie] ; Anthony Balmforth [Royaume-Uni] ; Alistair S. Hall [Royaume-Uni] ; Jeanette Erdmann [Allemagne] ; Francois Cambien [France] ; Panos Deloukas [Royaume-Uni] ; Christian Hengstenberg [Allemagne] ; Chris Packard [Royaume-Uni] ; Heribert Schunkert ; Willem H. Ouwehand [Royaume-Uni] ; Ian Ford [Royaume-Uni] ; Alison H. Goodall [Royaume-Uni] ; Mark A. Jobling [Royaume-Uni] ; Nilesh J. Samani [Royaume-Uni] ; Maciej Tomaszewski [Royaume-Uni]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2012.

RBID : Pascal:12-0137534

Descripteurs français

Pascal (Inist)
- Cardiopathie coronaire, Hérédité, Héritage, Homme, Mâle, Adulte, Chromosome Y, Médecine.
Wicri :
- topic : Héritage, Homme, Adulte, Médecine.

English descriptors

KwdEn :
- Adult, Coronary heart disease, Human, Inheritance, Inheritance(genetics), Male, Medicine, Y-Chromosome.

Abstract

Background A sexual dimorphism exists in the incidence and prevalence of coronary artery disease-men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. Methods We genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study. On the basis of this information, each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups. We then examined associations between common Y chromosome haplogroups and the risk of coronary artery disease in cross-sectional BHF-FHS and prospective WOSCOPS. Finally, we undertook functional analysis of Y chromosome effects on monocyte and macrophage transcriptome in British men from the Cardiogenics Study. Findings Of nine haplogroups identified, two (R1b1b2 and I) accounted for roughly 90% of the Y chromosome variants among British men. Carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y chromosome lineages in BHF-FHS (odds ratio 1.75, 95% CI 1.20-2.54, p=0.004), WOSCOPS (1-45, 1.08-1.95, p=0.012), and joint analysis of both populations (1.56, 1.24-1.97, p=0.0002). The association between haplogroup I and increased risk of coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors. Analysis of macrophage transcriptome in the Cardiogenics Study revealed that 19 molecular pathways showing strong differential expression between men with haplogroup I and other lineages of the Y chromosome were interconnected by common genes related to inflammation and immunity, and that some of them have a strong relevance to atherosclerosis. Interpretation The human Y chromosome is associated with risk of coronary artery disease in men of European ancestry, possibly through interactions of immunity and inflammation. Funding British Heart Foundation; UK National Institute for Health Research; LEW Carty Charitable Fund; National Health and Medical Research Council of Australia; European Union 6th Framework Programme; Wellcome Trust.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314981

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome</title>
<author><name sortKey="Charchar, Fadi J" sort="Charchar, Fadi J" uniqKey="Charchar F" first="Fadi J." last="Charchar">Fadi J. Charchar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bloomer, Lisa D S" sort="Bloomer, Lisa D S" uniqKey="Bloomer L" first="Lisa D. S." last="Bloomer">Lisa D. S. Bloomer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barnes, Timothy A" sort="Barnes, Timothy A" uniqKey="Barnes T" first="Timothy A." last="Barnes">Timothy A. Barnes</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J." last="Cowley">Mark J. Cowley</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Peter Wills Bioinformatics Centre, Garvan Institute for Medical Research</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Sydney, NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanzhong Wang" sort="Yanzhong Wang" uniqKey="Yanzhong Wang" last="Yanzhong Wang">YANZHONG WANG</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Division of Health and Social Care Research, King's College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denniff, Matthew" sort="Denniff, Matthew" uniqKey="Denniff M" first="Matthew" last="Denniff">Matthew Denniff</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Debiec, Radoslaw" sort="Debiec, Radoslaw" uniqKey="Debiec R" first="Radoslaw" last="Debiec">Radoslaw Debiec</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Christofidou, Paraskevi" sort="Christofidou, Paraskevi" uniqKey="Christofidou P" first="Paraskevi" last="Christofidou">Paraskevi Christofidou</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nankervis, Scott" sort="Nankervis, Scott" uniqKey="Nankervis S" first="Scott" last="Nankervis">Scott Nankervis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institute of Cardiovascular and Medical Sciences, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Bani Mustafa, Ahmed" sort="Bani Mustafa, Ahmed" uniqKey="Bani Mustafa A" first="Ahmed" last="Bani-Mustafa">Ahmed Bani-Mustafa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balmforth, Anthony" sort="Balmforth, Anthony" uniqKey="Balmforth A" first="Anthony" last="Balmforth">Anthony Balmforth</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Epidemiology, LIGHT, School of Medicine, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Epidemiology, LIGHT, School of Medicine, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Universitat zu Liibeck, Medizinische Klinik Il</s1>
<s2>Lijbeck</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Lijbeck</wicri:noRegion>
<wicri:noRegion>Medizinische Klinik Il</wicri:noRegion>
<wicri:noRegion>Lijbeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM UMRS 937, Pierre and Marie Curie University and Medical School</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Klinik und Poliklinik für Innere Medizin II, Universität Regensburg</s1>
<s2>Regensburg</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Regensburg</wicri:noRegion>
<wicri:noRegion>Universität Regensburg</wicri:noRegion>
<wicri:noRegion>Regensburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Vascular Biochemistry, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
</author>
<author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Haematology, University of Cambridge and National Health Service Blood and Transplant</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Robertson Centre for Biostatistics , College of Medicine, Veterinary and Life Sciences, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jobling, Mark A" sort="Jobling, Mark A" uniqKey="Jobling M" first="Mark A." last="Jobling">Mark A. Jobling</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Genetics, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0137534</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0137534 INIST</idno>
<idno type="RBID">Pascal:12-0137534</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001533</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004979</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001004</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001004</idno>
<idno type="wicri:doubleKey">0140-6736:2012:Charchar F:inheritance:of:coronary</idno>
<idno type="wicri:Area/Main/Merge">005E39</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314981</idno>
<idno type="RBID">PMC:3314981</idno>
<idno type="wicri:Area/Pmc/Corpus">002736</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002736</idno>
<idno type="wicri:Area/Pmc/Curation">002586</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002586</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001E83</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E83</idno>
<idno type="wicri:Area/Ncbi/Merge">000D16</idno>
<idno type="wicri:Area/Ncbi/Curation">000D16</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D16</idno>
<idno type="wicri:doubleKey">0140-6736:2012:Charchar F:inheritance:of:coronary</idno>
<idno type="wicri:Area/Main/Merge">005569</idno>
<idno type="wicri:Area/Main/Curation">005B38</idno>
<idno type="wicri:Area/Main/Exploration">005B38</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome</title>
<author><name sortKey="Charchar, Fadi J" sort="Charchar, Fadi J" uniqKey="Charchar F" first="Fadi J." last="Charchar">Fadi J. Charchar</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bloomer, Lisa D S" sort="Bloomer, Lisa D S" uniqKey="Bloomer L" first="Lisa D. S." last="Bloomer">Lisa D. S. Bloomer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barnes, Timothy A" sort="Barnes, Timothy A" uniqKey="Barnes T" first="Timothy A." last="Barnes">Timothy A. Barnes</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J." last="Cowley">Mark J. Cowley</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Peter Wills Bioinformatics Centre, Garvan Institute for Medical Research</s1>
<s2>Sydney, NSW</s2>
<s3>AUS</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Sydney, NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanzhong Wang" sort="Yanzhong Wang" uniqKey="Yanzhong Wang" last="Yanzhong Wang">YANZHONG WANG</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Division of Health and Social Care Research, King's College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denniff, Matthew" sort="Denniff, Matthew" uniqKey="Denniff M" first="Matthew" last="Denniff">Matthew Denniff</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Debiec, Radoslaw" sort="Debiec, Radoslaw" uniqKey="Debiec R" first="Radoslaw" last="Debiec">Radoslaw Debiec</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Christofidou, Paraskevi" sort="Christofidou, Paraskevi" uniqKey="Christofidou P" first="Paraskevi" last="Christofidou">Paraskevi Christofidou</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nankervis, Scott" sort="Nankervis, Scott" uniqKey="Nankervis S" first="Scott" last="Nankervis">Scott Nankervis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institute of Cardiovascular and Medical Sciences, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Bani Mustafa, Ahmed" sort="Bani Mustafa, Ahmed" uniqKey="Bani Mustafa A" first="Ahmed" last="Bani-Mustafa">Ahmed Bani-Mustafa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Health Sciences, University of Ballarat</s1>
<s2>Ballarat, VIC</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Ballarat, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balmforth, Anthony" sort="Balmforth, Anthony" uniqKey="Balmforth A" first="Anthony" last="Balmforth">Anthony Balmforth</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Epidemiology, LIGHT, School of Medicine, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Epidemiology, LIGHT, School of Medicine, University of Leeds</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
<orgName type="university">Université de Leeds</orgName>
</affiliation>
</author>
<author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Universitat zu Liibeck, Medizinische Klinik Il</s1>
<s2>Lijbeck</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Lijbeck</wicri:noRegion>
<wicri:noRegion>Medizinische Klinik Il</wicri:noRegion>
<wicri:noRegion>Lijbeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM UMRS 937, Pierre and Marie Curie University and Medical School</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Klinik und Poliklinik für Innere Medizin II, Universität Regensburg</s1>
<s2>Regensburg</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Regensburg</wicri:noRegion>
<wicri:noRegion>Universität Regensburg</wicri:noRegion>
<wicri:noRegion>Regensburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Vascular Biochemistry, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
</author>
<author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Haematology, University of Cambridge and National Health Service Blood and Transplant</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Robertson Centre for Biostatistics , College of Medicine, Veterinary and Life Sciences, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jobling, Mark A" sort="Jobling, Mark A" uniqKey="Jobling M" first="Mark A." last="Jobling">Mark A. Jobling</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Genetics, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cardiovascular Sciences, University of Leicester</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Coronary heart disease</term>
<term>Human</term>
<term>Inheritance</term>
<term>Inheritance(genetics)</term>
<term>Male</term>
<term>Medicine</term>
<term>Y-Chromosome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term>
<term>Hérédité</term>
<term>Héritage</term>
<term>Homme</term>
<term>Mâle</term>
<term>Adulte</term>
<term>Chromosome Y</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Héritage</term>
<term>Homme</term>
<term>Adulte</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background A sexual dimorphism exists in the incidence and prevalence of coronary artery disease-men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. Methods We genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study. On the basis of this information, each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups. We then examined associations between common Y chromosome haplogroups and the risk of coronary artery disease in cross-sectional BHF-FHS and prospective WOSCOPS. Finally, we undertook functional analysis of Y chromosome effects on monocyte and macrophage transcriptome in British men from the Cardiogenics Study. Findings Of nine haplogroups identified, two (R1b1b2 and I) accounted for roughly 90% of the Y chromosome variants among British men. Carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y chromosome lineages in BHF-FHS (odds ratio 1.75, 95% CI 1.20-2.54, p=0.004), WOSCOPS (1-45, 1.08-1.95, p=0.012), and joint analysis of both populations (1.56, 1.24-1.97, p=0.0002). The association between haplogroup I and increased risk of coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors. Analysis of macrophage transcriptome in the Cardiogenics Study revealed that 19 molecular pathways showing strong differential expression between men with haplogroup I and other lineages of the Y chromosome were interconnected by common genes related to inflammation and immunity, and that some of them have a strong relevance to atherosclerosis. Interpretation The human Y chromosome is associated with risk of coronary artery disease in men of European ancestry, possibly through interactions of immunity and inflammation. Funding British Heart Foundation; UK National Institute for Health Research; LEW Carty Charitable Fund; National Health and Medical Research Council of Australia; European Union 6th Framework Programme; Wellcome Trust.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Yorkshire-et-Humber</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement><li>Glasgow</li>
<li>Leeds</li>
<li>Londres</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Glasgow</li>
<li>Université de Leeds</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Charchar, Fadi J" sort="Charchar, Fadi J" uniqKey="Charchar F" first="Fadi J." last="Charchar">Fadi J. Charchar</name>
</noRegion>
<name sortKey="Bani Mustafa, Ahmed" sort="Bani Mustafa, Ahmed" uniqKey="Bani Mustafa A" first="Ahmed" last="Bani-Mustafa">Ahmed Bani-Mustafa</name>
<name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J." last="Cowley">Mark J. Cowley</name>
<name sortKey="Nankervis, Scott" sort="Nankervis, Scott" uniqKey="Nankervis S" first="Scott" last="Nankervis">Scott Nankervis</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Bloomer, Lisa D S" sort="Bloomer, Lisa D S" uniqKey="Bloomer L" first="Lisa D. S." last="Bloomer">Lisa D. S. Bloomer</name>
</noRegion>
<name sortKey="Balmforth, Anthony" sort="Balmforth, Anthony" uniqKey="Balmforth A" first="Anthony" last="Balmforth">Anthony Balmforth</name>
<name sortKey="Barnes, Timothy A" sort="Barnes, Timothy A" uniqKey="Barnes T" first="Timothy A." last="Barnes">Timothy A. Barnes</name>
<name sortKey="Christofidou, Paraskevi" sort="Christofidou, Paraskevi" uniqKey="Christofidou P" first="Paraskevi" last="Christofidou">Paraskevi Christofidou</name>
<name sortKey="Debiec, Radoslaw" sort="Debiec, Radoslaw" uniqKey="Debiec R" first="Radoslaw" last="Debiec">Radoslaw Debiec</name>
<name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<name sortKey="Denniff, Matthew" sort="Denniff, Matthew" uniqKey="Denniff M" first="Matthew" last="Denniff">Matthew Denniff</name>
<name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<name sortKey="Hall, Alistair S" sort="Hall, Alistair S" uniqKey="Hall A" first="Alistair S." last="Hall">Alistair S. Hall</name>
<name sortKey="Jobling, Mark A" sort="Jobling, Mark A" uniqKey="Jobling M" first="Mark A." last="Jobling">Mark A. Jobling</name>
<name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name>
<name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P." last="Nelson">Christopher P. Nelson</name>
<name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name>
<name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name>
<name sortKey="Packard, Chris" sort="Packard, Chris" uniqKey="Packard C" first="Chris" last="Packard">Chris Packard</name>
<name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name>
<name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name>
<name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<name sortKey="Yanzhong Wang" sort="Yanzhong Wang" uniqKey="Yanzhong Wang" last="Yanzhong Wang">YANZHONG WANG</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name>
</noRegion>
<name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005B38 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005B38 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0137534
   |texte=   Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.